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Diethylstilbestrol (DES) during pregnancy

Diethylstilbestrol, or DES, is a synthetic estrogen. It is often prescribed to women as hormone replacement therapy, or HRT treatment, during menopause.

Diethylstilbestrol has also been found to be effective against cancer. Only small doses of the drug are required, and it is used primarily to treat breast cancer in women and prostate cancer in men.

How diethylstilbestrol works

A synthetic form of estrogenOne of a group of female hormonal steroids that promote secondary sex characteristics.
Created in the ovaries, adrenal cortices, and fetoplacental unit, estrogen is used to prepare the genital tract for fertilization, implantation and nutrition of the embryo.
Estrogen is a key ingredient in oral contraceptives. Estrogens include conjugated estrogen, esterified estrogen, estradiol, estriol and estrone.
Visit our comprehensive glossary for more pregnancy terms and definitions.
, diethylstilbestrol can block the action of other hormonesA complex chemical substance created in a part or organ of the body. When released it initiates or regulates activity in an organ or group of cells in another part of the body.
Hormones secreted by endocrine glands are transported through the bloodstream to their target organ. The amount of hormone secreted is regulated either by other hormones, by neurotransmitters, or simply when an excess of the organ's activity indicates a need to reduce the amount of the hormone produced.
Other hormones are produced locally by the organs themselves and are common in the digestive tract.
Visit our comprehensive glossary for more pregnancy terms and definitions.
that promote the growth of tumors thus slowing the progress of cancer.

Diethylstilbestrol (DES) and pregnancy

Diethystilbestrol should not be used during pregnancy. The drug can cause congenital abnormalities of the female reproductive organs and may increase the risk of male and female infertility.

Breastfeeding is not recommended while using diethylstilbestrol.

Diethylstilbestrol should not be used by infants and children.

Known food interactions

There are no known food interactions with diethystilbestrol.

Alcohol should not be consumed while using this drug.

Disease interactions

Consult your doctor if you have a history of any of the following:

Reasons to consult your doctor

  • Contact your doctor immediately if you experience any of the following symptoms:
  • breast pain or increase in breast size
  • swollen feet and lower legs
  • rapid weight gain
  • irregular vaginal bleeding
  • painful menstrual periods
  • lumps in the breasts
  • pain in the: stomach, side or abdomen, chest, groin or legs
  • jerky muscle movements
  • yellow tinge in the eyes or skin (symptom of jaundice)
  • sudden or severe headaches
  • loss of coordination
  • loss or change of vision
  • sudden shortness of breath (dyspnea)
  • weakness in the arms or legs
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